Confused about the different kinds of omega-3 supplements? A recent study published by researchers at the University of Kansas Medical Center and Bill Harris of OmegaQuant compared the effects of prescription fish oil, supplemental fish oil and a krill oil blend on the Omega-3 Index and triglyceride levels1. The study was designed to test the claim that krill oil is more potent than prescription or supplemental fish oil pills.

Three groups of 10 healthy adults with moderately elevated triglycerides were assigned to one of three different types of commonly available omega-3 supplements – prescription fish oil, supplemental fish oil, and a krill oil blend.  Both fish oil blends provided over 3 g of EPA+DHA per day whereas the krill oil blend only provided ~1 g of EPA+DHA.  This discrepancy was done to test the hypothesis that krill oil is more potent than fish oil, or in other words, can increase the Omega-3 Index with a lower dose.

At the end of 6 weeks, both fish oil groups experienced a significant reduction in triglycerides (~25%), but this was not seen with krill oil. The fish oil products also increased the Omega-3 Index ~3 points (ex: 5.0% to 8.0%) and the krill oil blend increased it by ~2 points.  If we consider the increase per gram of EPA+DHA (because the fish oil supplements had ~3x the amount as the krill oil), the krill oil blend was almost twice as potent as the fish oil in increasing the Omega-3 Index.

In this study, a higher dose fish oil was more effective at lowering triglycerides and increasing the Omega-3 Index than a lower dose of krill oil blend. However, we don’t know if the krill oil being a “blend” made it less potent and perhaps pure krill oil would have met the claims of being 3x as potent as fish oil.  Most krill oil products on the market are blends so this point may be moot. Even so, triglycerides were not affected by the krill oil blend which may be due to the lower dose or point to a different mode of action between the types of omega-3 supplements. More research in this area is needed to make better recommendations for omega-3 supplementation.


1 Backes JM et al. Evaluating the effects of prescription fish oil, supplemental fish oil and krill oil blend on serum lipids/lipoproteins and the omega-3 index: a pilot study. Glycomics and Lipidomics (2014)

These statements have not been evaluated by the Food and Drug Administration. This test is not intended to diagnose, treat, cure, prevent or mitigate any disease. This site does not offer medical advice, and nothing contained herein is intended to establish a doctor/patient relationship. OmegaQuant, LLC is regulated under the Clinical Laboratory improvement Amendments of 1988 (CLIA) and is qualified to perform high complexity clinical testing. The performance characteristics of this test were determined by OmegaQuant, LLC. It has not been cleared or approved by the U.S. Food and Drug Administration.

Subscribe To Our Newsletter

Join our mailing list to receive the latest news and updates from OmegaQuant.

You have Successfully Subscribed!